Sidee si dhakhso ah loogu uuraysan karaa metformin? .
Dhakhaatiirta dumarka waxay isticmaalaan metformin oo qayb ka ah daaweynta si ay uur u yeeshaan; waxaan kuu sheegeynaa sida:
Metformin si aad uur yeelato
Dumarka leh caabbinta insulinta waxaa laga yaabaa inay kala duwan yihiin dhibaatooyinka dumarka , oo ay ku jirto dhib uur qaadistu. Sidaa darteed, dhakhaatiirta haweenka ayaa ka fiirsada metformin si ay uga caawiso dheddigga inay xakameyso iska caabbinta insulinta sidaasna ay ku ilaaliso wareegga caadada ku filan oo ay uur yeelato.
Metformin ma aha sida daaweynta dhalmo la'aanta oo kale , laakiin waa waxay caawisaa habaynta wareegga caadada dumarka ay saameysay caabbinta insulinta iyo sidaas si sahal ah u gaaro uurka . Sidoo kale, haddii haweeneydu ay xakameyso iska caabinta insulinta, ma uureysan doonto oo kaliya ee waxay si weyn u yareyn doontaa halista ah inay weydo ilmaha bilaha soo socda ee uurka.
Marka haweeneydu awooddo inay dheellitirto heerka hormoonkeeda, waxay muujineysaa Dhakhtarka Gudaha José Víctor Manuel Rincón Ponce, oo ka tirsan Machadka Badbaadada Bulshada ee Meksiko, wareegyada caadadeeda sidoo kale waa la sharciyeeyay, sidaa darteedna way fududaan doontaa in la abuuro jawi ku habboon jirkeeda yeelato oo aad haysato uur waqti buuxa ah.
Uur qaadista silica polycystic ovary syndrome
Cudurka ugxansidaha polycystic, oo ah cilad lagu garto caadada aan caadiga ahayn, isbeddel hormoon, iyo muuqaalka fiix badan oo ugxan -sidaha, wuxuu saameeyaa qiyaastii 8% dadweynaha dheddigga ah. Waxa keena cudurkan weli shaki ayaa ku jira, ogaanshaha iyo daaweynta ayaa aad looga dooday.
Waxa la og yahay in tani ay tahay mid ka mid ah sababaha ugu waaweyn ee dhalmo la'aanta dumarka, taas oo aad ku dari karto qaar ka mid ah xanuunnada dheef -shiid kiimikaadka, sida cayilka ama caabbinta insulinta.
Daraasad ay sameeyeen koox cilmi baarayaal ah oo ka kala socday jaamacado kala duwan oo Maraykan ah, si ay u ansixiyaan natiijooyinka daraasadaha yaryar ee ku saabsan habka ugu fiican ee lagu daaweyn karo dhalmo la'aanta dumarka qaba cudurka ugxansidaha polycystic , oo lagu daabacay joornaalka The New England Journal of Medicine, wuxuu qeexayaa in dawadii hore loo isticmaalay inay kiciso ugxanta iyada oo loo marayo ficilkeeda hormoon-kicinta hormoonka, clomiphene citrate, ayaa ah ikhtiyaarka ugu fiican ee dumarka la ildaran cudurkan inay uur qaadaan , sidoo kale waa daaweynta ugu fudud, raqiis ah, badbaado leh oo wax ku ool ah.
Isticmaalkii ugu dambeeyay wuxuu ahaa metformin, daawo loo isticmaalay in lagu daweeyo nooca 2aad ee sonkorowga, taas oo hagaajinaysa gulukooska iyo uur -ku -taagga. Daraasadda waxaa lagu sameeyay 626 haween madhalays ah sababtuna tahay cilladdan waxayna u qaybiyeen saddex kooxood, hal koox ayaa heshay dawada antidiabetic (sii-deynta sii-deynta metformin), koox kale oo soo-kicinta ugxanta (clomiphene citrate) iyo tan saddexaad waxay heshay isku-darka daawooyinka . Daaweynta iyo dabagalku waxay socdeen ugu badnaan 30 toddobaad ama ilaa ay ka gaaraan uur.
Dhamaadkii daraasadda, haweenka helay clomiphene waxay muujiyeen heerka dhalmada oo saddex jeer ka sarreeya kuwa kooxda metformin; Intaa waxaa dheer, kii hore wuxuu kaloo lahaa tiro badan oo uur badan.
Kuwii qaatay isku -darka labada daawooyinba waxay muujiyeen heerka ugxantu inuu ka sarreeyo inta kale, laakiin dhalashada lama fulin, in kasta oo ay uur -ku -jirro badan la bar -barteen kooxdii heshay soo -kiciyaha ugxanta.
Daraasadihii hore waxay soo jeediyeen wax ka soo horjeedda tan, laakiin natiijada lama falanqayn markay dhasheen, laakiin heerka ugxanta, oo aan ahayn rabitaanka dumarka la ildaran cudurkan.
Tixraacyo:
Daawo Joornaalka Macluumaad dheeraad ah
- Barbieri RL, et al. (2017). Metformin si loogu daaweeyo cilladda ugxansidaha polycystic.
uptodate.com/contents/metformin-for-treatment-of-the-polycystic-ovary-syndrome - Ka go'an doorashooyin caafimaad qaba si ay kaaga caawiyaan ka hortagga cilladaha dhalashada. (2017).
cdc.gov/ncbddd/birthdefects/prevention.html - Feig DS, et al. (2011). Daaweynta Metformin inta aad uurka leedahay. DOI:
doi.org/10.2337/dc11-1153 - Glucophage (metformin hydrochloride) kiniiniga; Glucophage XR (metformin hydrochloride) kiniinno sii-dheeraynta ah. (2017).
accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf - Shaqaalaha Mayo Clinic. (2017). Sonkorowga uurka.
mayoclinic.org/diseases-conditions/gestational-diabetes/basics/risk-factors/con-20014854
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